SRSLY™ supports methylation sequencing workflows by enabling NGS library preparation from methyl-converted inputs. Particularly, with bisulfite-converted DNA, SRSLY captures the highly fragmented DNA generated during bisulfite conversion and can work with very low input amounts. Regardless of the conversion method used, SRSLY circumvent the 2nd strand synthesis step - this enables more reliable DNA methylation analysis from limited or challenging samples.

Use our SRSLY NanoPlus or PicoPlus Uracil+ kit with Uracil-tolerant Polymerase for general Methyl-Seq applications from cfDNA and FFPE along with your choice of methyl-conversion kits.

Contact us to learn about our NEW! SRSLY MethylPlus Product that allows both fragmentomics and methylomics from cfDNA

KEY DATA HIGHLIGHTS