SRSLY® FOR cfDNA applications

SRSLY® captures features of circulating cell-free DNA (cfDNA) to support high-complexity NGS library preparation. Its high sensitivity enables reliable measurement of low-input, highly fragmented cfDNA commonly found in liquid biopsy samples. By reducing measurement bias and sample handling variability, SRSLY helps improve consistency and confidence in cfDNA sequencing workflows.

With PicoPlus and NanoPlus Kits you can work with inputs as low as 250 pg to 50ng.

key data hightlights

Captures Nicked DNA Lost in dsPreps22.jpg

Generate High Complexity cfDNA Libraries27.jpg

Capture ultra short DNA - Plasma and Urine26.jpg

SRSLY SIGHTINGS:

Check out the latest publications and preprints that cite SRSLY or our original technology paper in cfDNA application

featured application notes

Featured

cfDNA, Fragmentomics, SRSLY

AMP 2025 Poster - cfDNA fragmentomics

cfDNA, Fragmentomics, SRSLY

SRSLY, Methyl-Seq, Fragmentomics, cfDNA

ASHG 2025 Poster - cfDNA fragmentomics and methylomics

SRSLY, Methyl-Seq, Fragmentomics, cfDNA

aDNA, SRSLY

AGBT Ag 2022 Poster - Hair DNA with SRSLY

aDNA, SRSLY

REALLY, RNA-Seq, FFPE-RNA, SRSLY

ABGT PH 2025 - REALLY Poster

REALLY, RNA-Seq, FFPE-RNA, SRSLY

cfDNA, Fragmentomics, SRSLY

CNAPS 2024 Poster - cfDNA fragmentomics

cfDNA, Fragmentomics, SRSLY

cfDNA, SRSLY, Fragmentomics

ASHG 2024 Poster - cfDNA Fragmentomics

cfDNA, SRSLY, Fragmentomics

FFPE-RNA, FFPE-DNA, SRSLY, ForShear, REALLY

Signal Over DIN

FFPE-RNA, FFPE-DNA, SRSLY, ForShear, REALLY

FFPE-DNA, ForShear, SRSLY

Get the Best Data from the Wort Samples

FFPE-DNA, ForShear, SRSLY

aDNA, Hair, SRSLY

Ancient DNA Libraries from Rootless Hair

aDNA, Hair, SRSLY

SRSLY, Methyl-Seq, FFPE-DNA, gDNA, cfDNA

SRSLY for Methyl-Seq

SRSLY, Methyl-Seq, FFPE-DNA, gDNA, cfDNA

SRSLY, REALLY, RNA-Seq, FFPE-RNA, RNA

SRSLY for directional RNA-Seq

SRSLY, REALLY, RNA-Seq, FFPE-RNA, RNA

SRSLY, Oligo

SRSLY for Oligo QC

SRSLY, Oligo

SRSLY, MethylPlus, cfDNA, Fragmentomics, Methyl-Seq

SRSLY for Methylomics and Fragmentomics

SRSLY, MethylPlus, cfDNA, Fragmentomics, Methyl-Seq

SRSLY, Alternative Sequencers, gDNA, cfDNA

SRSLY on Aviti System - Element Bioscience

SRSLY, Alternative Sequencers, gDNA, cfDNA

cfDNA, FFPE-DNA, FFPE-RNA, RNA, SRSLY, REALLY, Alternative Sequencers

SRSLY Library on Singular Genomics G4 Platform

cfDNA, FFPE-DNA, FFPE-RNA, RNA, SRSLY, REALLY, Alternative Sequencers

SRSLY, Automation, cfDNA, FFPE-DNA, FFPE-RNA

SRSLY Library Preparation on Agilent Bravo

SRSLY, Automation, cfDNA, FFPE-DNA, FFPE-RNA

cfDNA, SRSLY, Control-DNA, Variant-Calling, Hybrid Capture

SRSLY for Variant Calling from cfDNA

cfDNA, SRSLY, Control-DNA, Variant-Calling, Hybrid Capture

SRSLY, REALLY, RNA-Seq, rNONE, FFPE-RNA, RNA, Hybrid Capture, Variant-Calling

SARS-CoV2 Variant Analysis with SRSLY

SRSLY, REALLY, RNA-Seq, rNONE, FFPE-RNA, RNA, Hybrid Capture, Variant-Calling

cfDNA, FFPE, FFPE-DNA, FFPE-RNA, REALLY, Fragmentomics, SRSLY, Oligo, ForShear, Automation

Clarefy™ Beads for SRSLY Library Prep

cfDNA, FFPE, FFPE-DNA, FFPE-RNA, REALLY, Fragmentomics, SRSLY, Oligo, ForShear, Automation

cfDNA, Fragmentomics, SRSLY

Single-stranded Approaches of cfDNA Fragmentomics

cfDNA, Fragmentomics, SRSLY

cfDNA, SRSLY, Variant-Calling, Exome, Hybrid Capture

Exome analysis with SRSLY and Twist Hybrid Capture on cfDNA

cfDNA, SRSLY, Variant-Calling, Exome, Hybrid Capture

ForShear, SRSLY, FFPE-DNA, FFPE, gDNA, Clarefy Beads

ForShear>SRSLY Workflow

ForShear, SRSLY, FFPE-DNA, FFPE, gDNA, Clarefy Beads

cfDNA, Fragmentomics, Methyl-Seq, SRSLY, MethylPlus

Methyl-Seq workflow - Library Prep Upstream

cfDNA, Fragmentomics, Methyl-Seq, SRSLY, MethylPlus

gDNA, cfDNA, FFPE-DNA, Methyl-Seq, SRSLY

Methyl-Seq workflow - Library Prep Downstream

gDNA, cfDNA, FFPE-DNA, Methyl-Seq, SRSLY

WEBINARS and Videos

Featured

THE SERIOUS TALK - 10 - Emmy Wesdorp

In this webinar Dr. Emmy Wesdorp will highlight the findings of their paper published earlier this year on https://www.nature.com/articles/s41525-025-00482-8 that evaluated computational and NGS methods to detect and profile Aspergillus in brocheoalveolar lavage from pediatric patients.

PMWC 2025 - ClaretBio Showcase Presentation

The SERIOUS Talk-2

In this webinar, Jordan Cheng (UCLA, School of Dentistry) describes the development of an extraction methods to capture highly degraded cell-free DNA from urine and plasma. A new class of cfDNA called ultra-short cell-free DNA are retained by this method and provides improved insights to the origin of cfDNA.

RELEVANT KITS AND MODULES

QUESTIONS

QUOTES AND ORDERS

SRSLY® FOR cfDNA applications

key data hightlights

SRSLY SIGHTINGS:

featured application notes

WEBINARS and Videos

RELEVANT KITS AND MODULES

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