SRSLY® cfDNA applications

Use our SRSLY PicoPlus and NanoPlus Kits for your cfDNA applications - rare variant calling to fragmentomics

SRSLY cfDNA Library from Urine and Plasma cfDNA

Comparison of base composition of cfDNA termini in SRSLY vs dsPrep libraries

Library complexity for cfDNA library with SRSLY vs dsPrep (1-10ng)

Capture of nicked DNA from plasma SRSLY vs dsPrep

application notes on cfDNA

Simple workflows for complex libraries: SRSLY® on the AVITITM System

This data spotlight demonstrates the compatibility of ClaretBio’s SRSLY library prep with the Element Biosciences’ AVITI™ Systems.

SRSLY Library Prep on the Agilent Bravo Liquid Handler

Reduce pipetting steps, gain hands free time! With the Bravo machine, you can prepare SRSLY libraries as easily as you would manually!

SEQUENCE SRSLY® LIBRARIES ON THE SINGULAR GENOMICS G4™ PLATFORM

SRSLY Libraries are now compatible with the Singular Genomics G4 Sequencing platform.

SARS-CoV-2 Targeted sequence analysis with SRSLY

This application note describes the utility of SRSLY in performing targeted sequence analysis of SAR-CoV-2 RNA-Seq libraries were generated with SRSLY within 3 hours. Subsequent enrichment of viral sequences can be performed with a user-preferred hybridization-based panel.

Target enrichment with SRSLY and Twist® Exome panel

SRSLY NGS library preparation with twist exome panel enrichment for ctDNA SNP profiling

Single-stranded approaches to Cell-Free DNA fragmentomics

Cell-free DNA (cfDNA), found circulating in blood plasma, contains a wealth of clinically relevant biological information which can be recovered by minimally-invasive procedures. Next Generation Sequencing (NGS) data obtained from cfDNA, can be used to monitor prenatal health, organ transplant reception or rejection, cancer and other diseases.

New! SRSLY for accurate variant calling in cell-free DNA

Using the Horizon Oncospan cfDNA standard and the Twist Bioscience pan-cancer enrichment panel, we showcase the utility of SRSLY NGS library preparation in ctDNA variant calling.

SRSLY Stringent Size Selection with Clarefy DNA Purification Beads

ClaretBio’s Clarefy Purification beads are the ultimate choice for retaining short DNA fragments. But we understand labs may have their own purification beads. We’ve put together a handy comparison how to still get the best SRSLY NGS libraries with other, 3rd party beads.

WEBINARS and Videos

Featured

PMWC 2025 - ClaretBio Showcase Presentation

The SERIOUS Talk-2

In this webinar, Jordan Cheng (UCLA, School of Dentistry) describes the development of an extraction methods to capture highly degraded cell-free DNA from urine and plasma. A new class of cfDNA called ultra-short cell-free DNA are retained by this method and provides improved insights to the origin of cfDNA.

The SERIOUS Talk-1

In this first-talk of the webinar series, Ms. Adrienne Chang (Cornell University) talks about the challenges in metagenomic assays from cfDNA. She highlights utility of single-stranded library preparation such as SRSLY in retaining short fragments and improving overall quality of the data obtained from difficult to sequence DNA inputs

SRSLY SIGHTINGS:

RELEVANT KITS AND MODULES

SRSLY DNA NGS Library Preparation Kit
UMI Addition Bundle
Clarefy Beads
Other supplies - NEBNext Enzymatic Methyl-conversion Module

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SRSLY® cfDNA applications

application notes on cfDNA

WEBINARS and Videos

SRSLY SIGHTINGS:

RELEVANT KITS AND MODULES

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