AMP 2026 · Seattle · Nov 11–14

Better libraries from less, and lower-quality, sample

Single-stranded library prep for cfDNA, FFPE and degraded DNA, plus methylation. Lower input and quality requirements, higher-complexity libraries.

Book a meeting at AMP View data for clinical applications (PDF)

Let's meet for coffee near the convention center, or at your lab in Seattle.

Meet Varsha Rao

VP, Partnerships & Clinical Collaboration

• In SeattleNov 10–14
• Lab visitsTuesday, Nov 10
• At AMPNov 11–14, by appointment
• Booth #813 (ClaretBio sister company Dovetail genomics)

Pick a time

~4x

More unique cfDNA molecules after capture

11–21M vs 2.8–4.9M · 5 ng patient plasma cfDNA · Vaske et al., AACR 2021

⅓

The duplicates on severely damaged DNA

13.5% vs 37.2% after exome capture · Horizon fcDNA · ForShear + SRSLY brochure

5–7%

Methylation underestimation avoided

End-repair bias in double-stranded cfDNA libraries · Groth et al., J Liquid Biopsy 2026

See the data for your sample type

Each one-pager fits a single phone screen, with the numbers, the conditions and the source.

SRSLY · cfDNA

Keep the short fragments other preps lose

SRSLY

11–21M

Double-stranded

2.8–4.9M

About 4x more unique molecules after hybrid capture, ~8% vs <1% of fragments in the 30–100 bp range, from 100 pg – 2 ng input.

cfDNA data →

ForShear + SRSLY · FFPE

More unique coverage from your worst samples

SRSLY

13.5%

Double-stranded

37.2%

One-third the duplicates and about 2.5x the library size on severely formalin-damaged reference DNA.

FFPE data →

SRSLY MethylPlus

Methylation calls without end-repair bias

Methylation and fragmentomics from one cfDNA library, 500 pg – 50 ng input. Works with commercially available enzymatic conversion kits.

SRSLY for Methyl-Seq data →

Find me at these sessions

If you're going too, say hello afterwards, or book a time and we'll meet nearby.

Thu Nov 12 · 10:15 AM

Fragmentation and methylation patterns in ctDNA for early cancer detection

Rooms 611–614, Level 6

Thu Nov 12 · 2:30 PM

AMP Clinical Validation of cfDNA and ctDNA Assays Working Group

Ballroom E, Level 6

Sat Nov 14 · 2:30 PM

Technical Advancement in Methylation Profiling

Rooms 608–609, Level 6

Ways to work with us

Start with our data or a trial with your own samples, and we can talk about other ways to collaborate.

Try it

• See our data for your sample type
• Pilot kits for your own samples
• Protocols for cfDNA, FFPE and methyl-seq
• Automation recommendations

Request pilot kits

Collaborate

• Joint studies and publications
• Technical support for your workflow
• Core service partnerships
• Other ways to work together – let's talk

Start a conversation

Peer-reviewed

The methods behind the data.

End-repair causes methylation underestimation in cell-free DNA sequencing librariesGroth TE, Mishin AA, Rao V, Tibet R, Troll CJ. The Journal of Liquid Biopsy 2026;11:100455.

A ligation-based single-stranded library preparation method to analyze cell-free DNA and synthetic oligosTroll CJ, Kapp J, Rao V, Harkins KM, Cole C, Naughton C, Morgan JM, Shapiro B, Green RE. BMC Genomics 2019;20:1023.

For Research Use Only. Not for use in diagnostic procedures.