This paper demonstrates the pitfalls of end-repair in cfDNA fragmentomics and methylation and how SRSLY retains vital cfDNA CpG methylation signals at read termini on 3’ and 5’ ends.

A ligation-based single-stranded library preparation method to analyze cell-free DNA and synthetic oligos

A novel method for oligonucleotide assembly and contig generation using splints.

A novel NGS library preparation method to characterize native termini of fragmented DNA