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SRSLY cfDNA METHYLATION PAPER > JAN 2026 This paper demonstrates the pitfalls of end-repair in cfDNA fragmentomics and methylation and how SRSLY retains vital cfDNA CpG methylation signals at read termini on 3’ and 5’ ends. https://static1.squarespace.com/static/5bfc82067e3c3a5bd7e61c54/5e9765a6edfe5706afcaf1fe/5e9765b822a7e72e3a05c375/1720645357928/ Publications https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1767632858223-07VZ4WCAHL2NJV6IKWXA/JLB-paper.png Publications - SRSLY cfDNA METHYLATION PAPER > JAN 2026 This paper demonstrates the pitfalls of end-repair in cfDNA fragmentomics and methylation and how SRSLY retains vital cfDNA CpG methylation signals at read termini on 3’ and 5’ ends. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1586983107383-RMWS6R219BUDXPM1EMEU/image-asset.jpeg Publications - SRSLY Methodology Paper > January 2020 A ligation-based single-stranded library preparation method to analyze cell-free DNA and synthetic oligos https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1735452619817-5PH28QZPPJS1A6FKKFJ5/Splynthesis.png Publications - SPLYNTHESIS METHOD PAPER > DEC 2024 A novel method for oligonucleotide assembly and contig generation using splints. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1586983123455-M9TAB7ULBLIRECV4BDC0/image-asset.jpeg Publications - XACTLY Methodology Paper > March 2020 A novel NGS library preparation method to characterize native termini of fragmented DNA https://www.claretbio.com/available-literature/posters daily 0.75 2025-10-31 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1761944117531-X5AY2IWPDRJXXLBX8O9D/AMP2025-Poster-Thumbnail.png Posters - AMP 2025 POSTER > NOV 2025 Use of single-stranded library preparation method in cfDNA fragmentomics https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1761944117531-X5AY2IWPDRJXXLBX8O9D/AMP2025-Poster-Thumbnail.png Posters - AMP 2025 POSTER > NOV 2025 Use of single-stranded library preparation method in cfDNA fragmentomics https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1761080863655-8XTBFM4UVOZTEE9AL609/ClaretBio-ASHG-Poster-2025_thumbnail.png Posters - ASHG 2025 RNA-SEQ POSTER > OCT 2025 Advantages of REALLY-rNONE in RNA-Seq from degraded samples. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1761080877433-LP89DD6G2MKNRMXI0KPM/ClaretBio-MethlySeq-ASHG_2025-Poster_thumbnaill.png Posters - ASHG 2025 cfDNA Methyl-Seq Poster > October 2025 Use of SRSLY captures cfDNA methylation signal lost due to end-repair in traditional library preparation methods. https://static1.squarespace.com/static/5bfc82067e3c3a5bd7e61c54/5e9772137faf6b481d009d68/5e97724c18f1651095146d29/1725555199697/ Posters - March 2020, Molecular Tri-Conference https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1733810651892-FFL5X78S7H6G02GODUPX/ClaretBio-ASHG_Poster_thumbnail.png Posters - ASHG POSTER > NOVEMBER 2024 Presenter: Tobin Groth Here we demonstrate the utility of ClaretBio’s SRSLY in cfDNA fragmetnomics for prostate cancer detection. Using a combined random forest and K-fold approach we show that 3’ of cfDNA are the most informative in differentiating between low grade prostate cancer and healthy individuals. The signal is captured at low depth of sequencing and is spread across the genome. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1725555213470-QH12VNU0ZM8190179SFO/ASHG-Poster-thumbnail.png Posters - CNAPS 24 Poster > MARCH 2024 Presenter: Varsha Rao Here we demonstrate the utility of SRSLY in cfDNA fragmentomics using a cohort of Myelodysplastic Syndrome (MDS) Patients and show that the method can differentiate a sub-group that shows abnormality in erythropoiesis - MDS-RS (Ring sideroblast) https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1665966621473-5BTKG446G9KCI9BFID63/ASHG-Poster-thumbnail.png Posters - ASHG 22 Poster > OCTOBER 2022 Presenter: Camille Schwartz This work demonstrates the utility of cfDNA fragmentomics in low-depth sequencing based diagnosis in Myelodysplastic Syndrome https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1655136299909-LBJOIVCI0NS6QFJYT20I/AGBT-AG-Poster-thumbnail.png Posters - AGBT-Agriculture 22 Poster > APRIL 2022 Rootless hair - an under-appreciated, non-invasive sample type for genomic analyses in animal husbandry contexts. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1586983827600-R5LBO8ACR74YSRP3PJSA/image-asset.jpeg Posters - Molecular Tri-Conference Poster > March 2020 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1586994874540-OHLLFBMB0SGQTKISK326/image-asset.jpeg Posters - AGBT Poster > March 2020 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1586995119778-P2CA2JSAXBOAO41LFJK7/image-asset.jpeg Posters - AGBT Precision Health Poster > August 2019 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1586995306903-UAIJUT17NOLIERRI4RGR/image-asset.jpeg Posters - Liquid Biopsy Symposium Poster > July 2019 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1708587112690-GYQ9S63VTN66M64RF82R/Poster-thumbnail.png Posters - CNAPS 2024 Poster Poster Presentation at CNAPS https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1756873522786-67HWREYKIUOKRT66DHVM/ClaretBio-AGBT-PH_Thumbnail-2025.png Posters - Improved RNA-Seq data from stored FFPE Tissue with REALLY-rNONE™ ClaretBio’s Poster Presentation at AGBT Precision Health 2025, showing their latest offering for RNA-Seq https://www.claretbio.com/application-notes daily 0.75 2025-04-12 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1744423233352-QMBR6BLSO8HXBYXGJVNT/EB_Data-Spotlight_Aviti-SRSLY_Digital_Letter-thumbnail.png Application Notes - Simple workflows for complex libraries: SRSLY® on the AVITITM System This data spotlight demonstrates the compatibility of ClaretBio’s SRSLY library prep with the Element Biosciences’ AVITI™ Systems. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1744423233352-QMBR6BLSO8HXBYXGJVNT/EB_Data-Spotlight_Aviti-SRSLY_Digital_Letter-thumbnail.png Application Notes - Simple workflows for complex libraries: SRSLY® on the AVITITM System This data spotlight demonstrates the compatibility of ClaretBio’s SRSLY library prep with the Element Biosciences’ AVITI™ Systems. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1698860710824-PNTSPB8K7P66DLCQ8GWC/Bravo-Automation-Thumbnail.png Application Notes - SRSLY Library Prep on the Agilent Bravo Liquid Handler Reduce pipetting steps, gain hands free time! With the Bravo machine, you can prepare SRSLY libraries as easily as you would manually! https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1681166952556-NBACYVI9FA9YQTWUS5JZ/SingularGenomics-Thumbnail.png Application Notes - SEQUENCE SRSLY® LIBRARIES ON THE SINGULAR GENOMICS G4™ PLATFORM SRSLY Libraries are now compatible with the Singular Genomics G4 Sequencing platform. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1597448082354-2YC0IRZPT2APBM1NV9NJ/SARS-thumbnail-BUTTON.jpg Application Notes - SARS-CoV-2 Targeted sequence analysis with SRSLY This application note describes the utility of SRSLY in performing targeted sequence analysis of SAR-CoV-2 RNA-Seq libraries were generated with SRSLY within 3 hours. Subsequent enrichment of viral sequences can be performed with a user-preferred hybridization-based panel. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1595302328696-BL5OPIE360YM5318X2U4/image-asset.jpeg Application Notes - Target enrichment with SRSLY and Twist® Exome panel SRSLY NGS library preparation with twist exome panel enrichment for ctDNA SNP profiling https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1595302548056-IZIO8W8WSJD91BYOST6J/ClaretBio_Single-stranded_Approaches.jpg Application Notes - Single-stranded approaches to Cell-Free DNA fragmentomics Cell-free DNA (cfDNA), found circulating in blood plasma, contains a wealth of clinically relevant biological information which can be recovered by minimally-invasive procedures. Next Generation Sequencing (NGS) data obtained from cfDNA, can be used to monitor prenatal health, organ transplant reception or rejection, cancer and other diseases. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1646499872152-1K2V3YDGH7BZ7E8SGURM/Horizon-cfDNA-Thumbnail.png Application Notes - New! SRSLY for accurate variant calling in cell-free DNA Using the Horizon Oncospan cfDNA standard and the Twist Bioscience pan-cancer enrichment panel, we showcase the utility of SRSLY NGS library preparation in ctDNA variant calling. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1596500607158-PUTU9PEJESHPG1CHB6Q2/ClaretBio_SRSLY_Clarefy_Beads.jpg Application Notes - SRSLY Stringent Size Selection with Clarefy DNA Purification Beads ClaretBio’s Clarefy Purification beads are the ultimate choice for retaining short DNA fragments. But we understand labs may have their own purification beads. We’ve put together a handy comparison how to still get the best SRSLY NGS libraries with other, 3rd party beads. https://www.claretbio.com/brochures-and-technical-notes daily 0.75 2026-01-12 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1768249853060-QKEQ62CBT9HXXNNG389U/Methyl-Seq-thumbnail.png Brochures - NEW! SRSLY® MethylPlus A specialized version of SRSLY that allows combined fragmentomics and methylomics. The workflow is agnostic of the enzymatic methyl conversion kit used. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1768249853060-QKEQ62CBT9HXXNNG389U/Methyl-Seq-thumbnail.png Brochures - NEW! SRSLY® MethylPlus A specialized version of SRSLY that allows combined fragmentomics and methylomics. The workflow is agnostic of the enzymatic methyl conversion kit used. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1739559620064-CX8TXH9GCPG8GWZEDK9Z/image-asset.png Brochures - SIGNAL OVER DIN (AND RIN) This data sheet demonstrates the advantages of ClaretBio’s suite of technologies in improving the quality of data captured from clinical samples of poor quality. Here, using DNA and RNA extracted from FFPE tissue that are of low DNA Integrity Number (DIN) or RNA Integrity Number (RIN), we show that the ForShear™>SRSLY® whole genome sequencing workflow and REALLY rNONE™ RNA-Seq workflow generate high quality data even with challenging samples https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1736547246758-XLQGD3P648L418M5G79C/REALLY-hg-rNONE-thumbnail.png Brochures - NEW! REALLY hg-rNONE for RNA-Seq with simultaneous ribosomal RNA and globin depletion Learn more about our offering (launch Feb 2025) - a workflow for RNA-Seq from whole blood or blood derived RNA with globin depletion. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1697433016449-NTJ1JRGK9B18A3BP8DLS/REALLY-brochure-thumbnail.png Brochures - REALLY-rNONE workflow for directional RNA-Seq library preparation ClaretBio’s newest offering brings a simplified RNA-Seq method, coupled with a robust ribo-depletion workflow https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1654289945447-VN8ERNXF0Q2KR5WDSNGJ/ClaretBio-Brochure-ForShear-thumbnail.png Brochures - ForShear and SRSLY a robust combination for NGS library prep from FFPE DNA Our new product, ForShear allows fragmentation of gDNA and seamless intergretion with SRSLY library preparation. Generate high-quality libraries from challenging low-quality severely damaged libraries. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1587139127793-RUJSNXRX8Y475FSAU9XO/image-asset.jpeg Brochures - SRSLY for cell-free DNA SRSLY™ a single-stranded approach to NGS library preparation for analysis of cell-free DNA fragments https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1587139223998-MINV385LIYBJEH6J55JW/ClaretBio_SRSLY_for_Hair_Ancient_DNA.jpg Brochures - SRSLY for Hair and Ancient DNA SRSLY™ a single-stranded approach to Illumina NGS library preparation for analysis of highly fragmented and low yield DNA https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1614991726519-86KRTYCYAOQFZ6HC7DOZ/OLIGO-THUMBNAIL-FULL.jpg Brochures - SRSLY FOR SUPERIOR NGS-BASED OLIGO QC SRSLY can be used for NGS-based quality control of synthetic oligonucleotides. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1587139497099-I6XRILRZ08PJY0T65JUT/ClaretBio_SRSLY_RNA-Seq.jpg Brochures - SRSLY for RNA-Seq Efficient single-stranded library method for RNA-Seq workflows https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1643680991091-889SHGXYDL5UT4CWHQYR/image-asset.png Brochures - XACTLY for cell-free DNA Fragmentomics DNA termini profiling assay for improved fragmentomics https://www.claretbio.com/literature/videos daily 0.75 2024-09-05 https://www.claretbio.com/literature/videos/2026/06/10/the-serious-talk-11 monthly 0.5 2026-02-10 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/50f26769-3a90-4d10-b281-2a56bf51e0ec/SERIOUS-TALK-11-Thumbnail.png Videos - THE SERIOUS TALK - 11 - SRSLY MethylPlus - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.claretbio.com/literature/videos/2025/8/26/the-serious-talk-9 monthly 0.5 2025-09-05 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/ba9285a0-97bd-48c6-87f9-ed75a00364d3/Serious-Webinar-9-image.png Videos - 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Catalog - SRSLY Library Preparation on Agilent Bravo https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1646499872152-1K2V3YDGH7BZ7E8SGURM/Horizon-cfDNA-Thumbnail.png All Images Catalog - SRSLY for Variant Calling from cfDNA https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1597448082354-2YC0IRZPT2APBM1NV9NJ/ClaretBio_SARS-COV-2_Application_Note.jpg All Images Catalog - SARS-CoV2 Variant Analysis with SRSLY https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1596500607158-PUTU9PEJESHPG1CHB6Q2/ClaretBio_SRSLY_Clarefy_Beads.jpg All Images Catalog - Clarefy™ Beads for SRSLY Library Prep https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1595302548056-IZIO8W8WSJD91BYOST6J/ClaretBio_Single-stranded_Approaches.jpg All Images Catalog - Single-stranded Approaches of cfDNA Fragmentomics https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1595302328696-BL5OPIE360YM5318X2U4/image-asset.jpeg All Images Catalog - Exome analysis with SRSLY and Twist Hybrid Capture on cfDNA https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/2bb25ea2-2d30-4f9d-a471-d9b9c40c00be/SRSLY-ForShear-Cartoon.png All Images Catalog - ForShear>SRSLY Workflow https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1767339865113-GYIUV02R149FA94CK78O/SRSLY-Methyl-Seq-Cartoon.png All Images Catalog - Methyl-Seq workflow - Library Prep Upstream https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1767339940539-6E9IXTOIVTG348EZPV8J/SRSLY-Methyl-Seq-upstream.png All Images Catalog - Methyl-Seq workflow - Library Prep Downstream https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/7b3e800d-56d5-47de-aae8-e0bb39fe8913/REALLY-rNONE-website.png All Images Catalog - REALLY rNONE workflow https://www.claretbio.com/our-crew daily 0.75 2025-07-20 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1560626242023-4ZNAOMDAF6LKL1XLHSKX/ClaretBio-Crew2-Banner.jpg Our Crew https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/839c3a20-96e8-4689-bb42-5eadb1607a57/2021_holiday_image.jpg Our Crew - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1548805395085-ALF06Q81O97JK9EWD87H/IMG_0866.JPG Our Crew https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1548805408013-DBIIJ7CXU7V6DOC3AO20/IMG_0796.JPG Our Crew https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1548805426800-0F2FH2ET701I727MYDGB/IMG_0797.JPG Our Crew https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1560576179999-C9FE602JBJC4BM4VHFS2/IMG_0791-1.jpg Our Crew https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1560576190802-HN6K85VDDZYDX8B9XWPH/IMG_0539-1.JPG Our Crew https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/9092745e-8e4b-4152-92b8-fe52b6aa2202/Claret-team-zoom.jpg Our Crew https://www.claretbio.com/xactly daily 0.75 2025-01-26 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1548292106015-C4TNSPJJS45P5T9BI4DG/ClaretBio-Xactly-Banner.jpg XACTLY™ https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1559940551664-72S4RK2A3CCE18TWJF71/XACTLY+webpage+workflow.png XACTLY™ https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1559941014978-UNQ26PZ3HX2T9LC8XRW5/XACTLY+master+figure+vertical.png XACTLY™ In this illustrated example we elucidate the cut site left by an uncharacterized restriction enzyme using XACTLY. HMW DNA is first digested with the restriction enzyme and then used as input into XACTLY. After the XACTLY protocol the library is sequenced and the data is analyzed with respect to their overhangs. The results show a high prevalence of reads contain 5´ 4 bp overhangs with a predominant base composition of roughly equal proportion of Guanine and Cytosine at the 5´ 4 bp overhang. Further analysis of the overhang motifs revel the 5´ 4 bp cut site to be GGCC. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1560348157878-OSM169UDCP6BTDNZ2CV9/Slide2.png XACTLY™ cfDNA fragment termini contain information about the molecular history and origin of the molecule. This wealth of information is currently overlooked or lost due to the limitations of existing library preparation technologies. XACTLY fills this precise gap and helps elucidate preceding events that lead to cfDNA formation. These mechanisms may differ in healthy and diseased conditions: for example, differential nucleosome positioning, or differences in nuclease type and function. These events can result in unique DNA fragmentation patterns and generate a cfDNA pool with mixture of discrete and complex overhang profiles specific to a biological state. Following capture of this information with XACTLY, sophisticated machine learning algorithms are used to identify termini biomarkers that distinguish diseased from healthy states. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1560634926989-TELUBUJBCIC9GKUR1Y4X/ClaretBio-XACTLY-compiled-brochure.jpg XACTLY™ - Check out our XACTLY Method in Action https://www.claretbio.com/careers daily 0.75 2025-02-11 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1549936762814-GPN54PBJ23B4MDHA7BJN/ClaretBio-Careers-Banner.jpg Careers https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1548964042565-AQN4X9ORR5D5ISCQQJU7/IMG_0866.JPG Careers https://www.claretbio.com/careers-form daily 0.75 2020-02-13 https://www.claretbio.com/termsandconditions daily 0.75 2024-05-08 https://www.claretbio.com/srsly-technology daily 0.75 2025-06-11 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1551463283679-CDJDWMGEZ9FQ8MG8REWF/ClaretBio-Srsly-Banner.jpg SRSLY Technology https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1569967560768-4XH7RUGB34Q2SIUFOU22/VennDiagram.png SRSLY Technology The unique molecular and informatic features of SRSLY that make it applicable to various types of input DNA https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1559336239918-H40VCOJD2IY9FTF326MW/Claret-SRSLY-DNA-Illustration.jpg SRSLY Technology SRSLY works in a one-step combined phosphorylation/ligation step that simultaneously prepares template DNA molecules for ligation without end-polishing and ligates Illumina adapters by utilizing proprietary splint adapters. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/69cbca30-1237-4622-b797-8b51d5453e2d/InputRange.png SRSLY Technology https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/d13b4885-bb1b-4de7-b26b-e6bf861b112f/LibraryPrepKitsCompareTable-noNames.png SRSLY Technology Methods - Sequencing libraries were generated from two healthy cfDNA extracts. The results between SRSLY and 3 commercially available library preparation methods were compared. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/6c5147f9-eded-4b56-8f79-4d0d22d56a38/Fig2_WhitePaper_Yield_noNames.png SRSLY Technology SRSLY Libraries Produce High DNA Yields - allowing users more flexibility with downstream manipulations prior to sequencing https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/73d45035-9de6-45a9-a8b0-8ff0be40feec/Seq-CompareTable-noNames.png SRSLY Technology SRSLY Post Index PCR Yields and Mapping Statistics Compared to Commercial Kits https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1640f576-ea5f-4853-87da-26f19a9928f7/Fig3_WhitePaper_Mapped+and+short+frag+merged_noName.png SRSLY Technology SRSLY Libraries Map with Accuracy and Retain More Short Fragments - Mapping performance of SRSLY is on par with the best commercial kits on the market. SRSLY goes above and beyond other kits by capturing a higher percentage of reads with short inserts (30-100 bp) to help researchers leverage valuable biology encoded in short cfDNA fragments. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/653bfe04-d018-4055-b583-6553487a28e9/Fig7_WhitePaper_GC_merged_noName.png SRSLY Technology SRSLY Libraries Produce Expected GC Coverage for cfDNA - cfDNA is known to have a higher fraction of GC rich sequences compared to gDNA. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/f07a5f1f-317c-439f-a0c9-45598dc1db20/Fig6_WhitePaper_PreSeq_combined_noName.png SRSLY Technology SRSLY Generates Complex Libraries - Retaining native termini with SRSLY does not mean sacrificing library complexity. SRSLY ensures you get the most out of your 1 ng input by creating complex libraries on par with the best commercial kits on the market. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1560541848869-KSLMW7VLL5GABYE24F0F/cfDNA+model2.png SRSLY Technology https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/b194582a-007a-4de6-9a89-dd098d3ae0a2/Fig4_WP_ISD_combined_peak+assign_noName.png SRSLY Technology https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/b87dfc22-d175-44c9-9a42-9f16c3be147b/Fig5_WP_ISD_Figure2_both_noName.png SRSLY Technology https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1573144903477-5UV2EJVJ6N6ZM0Q0JDTF/ClaretBio-SRSLY-Cell-Free-DNA-Brochure.jpg SRSLY Technology - SRSLY Cell-Free DNA Brochure https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1578712390173-SMALHHGK3RT5J0YX5PI8/ClaretBio-Hair-Brochure.jpg SRSLY Technology - SRSLY for aDNA & rootless hair Brochure https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1573147760369-GRDJ749RHI0D4XV6YI0B/ClaretBio-Fragmentomics-of+cfDNA-WP.jpg SRSLY Technology - White Paper: Fragmentomics of cfDNA https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1573145311623-Q1C7NWFK5QU65MDRTM79/ClaretBio-SRSLY-for-RNASeq-TechNote.jpg SRSLY Technology - Technical Note: SRSLY for RNASeq https://www.claretbio.com/contact-us daily 0.75 2025-07-07 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1552681697469-26XFVCB7LAHWLK8NKXOH/ClaretBio-ContactUs-Banner.jpg Contact https://www.claretbio.com/newsletter-signup daily 0.75 2019-10-31 https://www.claretbio.com/featured-literature daily 0.75 2022-06-21 https://www.claretbio.com/featured-literature/publications daily 0.75 2023-01-22 https://www.claretbio.com/featured-literature/application-notes daily 0.75 2024-11-12 https://www.claretbio.com/featured-literature/posters daily 0.75 2025-10-10 https://www.claretbio.com/featured-literature/brochures-and-technical-notes daily 0.75 2023-01-22 https://www.claretbio.com/srsly-conference-quote daily 0.75 2026-02-10 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1630356843371-TUKGBL0BRC524JU9IWUM/ClaretBio-quote-banner+copy.jpg CONFERENCE QUOTE https://www.claretbio.com/products/kits daily 0.75 2025-06-11 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1596841075152-UK85DHK45FJ247Q8LI4B/Claret-Bio-SRSLY-Kit-Banner.jpg Kits https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/871db54d-eef5-4d69-8b5a-656c5b0d1d34/Kit_option_table-REALLY-hgrNONE.png Kits REALLY hg-rNONE™ is our latest offering for RNA-Seq with hemoglobin- and ribo-depletion, a single modular bundles work for 10ng - 250ng total RNA. We offer two versions of our standard SRSLY® kits (with or without a uracil-tolerant index PCR polymerase). For DNA template types that contain uracil, such as aDNA, methyl-converted DNA, and some FFPE samples, consider purchasing the kit supplied with the uracil-tolerant index PCR polymerase. For all other template types, the standard index PCR polymerase is the best choice. If utilizing the SRSLY UMI add-on reagents choose the standard polymerase option regardless of input type. Visit our FAQs page or contact technicalsupport@claretbio.com for input-specific recommendations. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/41ddfd79-1fcd-48ab-bc0b-289e831d06d9/Modular-Q1-2025-hg-rNONE.png Kits Assemble your modular kit in this order: First 1. Choose a base kit and 2. choose the number of reactions. Then based on the reaction volume 3. choose either the UDI or UMI primer strategy and 4. choose your beads (not for REALLY bundle though, beads are included!), finally 5. for gDNA (FFPE or fresh frozen) application choose the enzymatic fragmentation module. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/d9082f56-7819-4764-9b5a-9145810be8b7/Kit-Nitty-Gritty-Apr2025.png Kits https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1596842110428-90OKO5ZXPU03RC7GGPX6/QC_Test.jpg Kits https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1596210697571-WQXSXGW2K6CUFYJHDPZY/QC_Pass_Parameters.jpg Kits https://www.claretbio.com/products/srsly-umi daily 0.75 2025-06-11 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1596491922448-EFZR1JT1JZKAYBY9PD8W/ClaretBio-Srsly-Banner.jpg SRSLYUMI-SOFTWARE https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1596772791741-LY4MSJJQFVM06MN9QU9W/SRSLY_UMI_Infomatics_Figure1.jpg SRSLYUMI-SOFTWARE https://www.claretbio.com/videos daily 0.75 2026-02-10 https://www.claretbio.com/products/kit-faqs daily 0.75 2025-03-28 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1596841075152-UK85DHK45FJ247Q8LI4B/Claret-Bio-SRSLY-Kit-Banner.jpg Kit FAQs https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/bd82796f-faa6-465c-88d9-38dc8f6c7103/Kit_option_table.png Kit FAQs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1620841479321-EG0E68RIWL21AMCD8QR0/Picture2.jpg Kit FAQs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1620842206303-4JO4BCNY4XCYYIO5QA83/Picture1.jpg Kit FAQs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1634757888597-PB00MJNWQIZ38IYM1QLF/Screen+Shot+2021-10-20+at+12.24.19+PM.png Kit FAQs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1634758058364-9LTHDEGBO7JC9IGZZ0H9/Screen+Shot+2021-10-20+at+12.27.30+PM.png Kit FAQs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1620772599883-B1ZN55O3PXD5T3MFDWKF/Screen+Shot+2021-05-11+at+3.36.17+PM.png Kit FAQs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1620774079577-GBIE7YOY3579TUKKYWS0/Screen+Shot+2021-05-11+at+4.01.06+PM.png Kit FAQs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.claretbio.com/products/services-custom-projects daily 0.75 2024-09-17 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1551463283679-CDJDWMGEZ9FQ8MG8REWF/ClaretBio-Srsly-Banner.jpg Services and Custom Projects https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1573144903477-5UV2EJVJ6N6ZM0Q0JDTF/ClaretBio-SRSLY-Cell-Free-DNA-Brochure.jpg Services and Custom Projects - SRSLY Cell-Free DNA Brochure https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1578712390173-SMALHHGK3RT5J0YX5PI8/ClaretBio-Hair-Brochure.jpg Services and Custom Projects - SRSLY for aDNA & rootless hair Brochure https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1573147760369-GRDJ749RHI0D4XV6YI0B/ClaretBio-Fragmentomics-of+cfDNA-WP.jpg Services and Custom Projects - White Paper: Fragmentomics of cfDNA https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1573145311623-Q1C7NWFK5QU65MDRTM79/ClaretBio-SRSLY-for-RNASeq-TechNote.jpg Services and Custom Projects - Technical Note: SRSLY for RNASeq https://www.claretbio.com/products/srsly-run daily 0.75 2024-07-03 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1596491922448-EFZR1JT1JZKAYBY9PD8W/ClaretBio-Srsly-Banner.jpg SRSLYRUN-SOFTWARE https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/0c1efa69-444d-4cf6-a2a0-3544ed4e6cf9/Software-workflow4.png SRSLYRUN-SOFTWARE SRSLYRUN software workflow. Raw FASTQ or BCL files are processed to generate a comprehensive data output. Steps in teal indicate processing of sequencing data without UMI and steps in yellow indicate processing of UMI-aware sequencing data. SRSLYumi must be run prior to processing UMI-aware data. https://www.claretbio.com/qualitypolicy daily 0.75 2025-10-10 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/13139931-0ec0-4336-a5d5-ebc3b640fe70/ClaretBioscience_ISO13485_Certificate.png Quality-Policy - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.claretbio.com/automation daily 0.75 2025-07-09 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1682011697013-E8PDDLGHDEFWSI4QRGKM/Claret+Bio+Banners.png Kit Automation https://www.claretbio.com/citations daily 0.75 2026-01-03 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1548965228744-JMWN2EKFHNODSYXDFDVY/ClaretBio-Homepage-Srsly-LG.jpg CITATIONS https://www.claretbio.com/srsly-quote daily 0.75 2026-01-14 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1552681697469-26XFVCB7LAHWLK8NKXOH/ClaretBio-ContactUs-Banner.jpg SRSLY Quote https://www.claretbio.com/app-note-downloads daily 0.75 2024-06-12 https://www.claretbio.com/poster-downloads daily 0.75 2025-10-31 https://www.claretbio.com/publications-downloads daily 0.75 2026-01-05 https://www.claretbio.com/product-msds daily 0.75 2025-10-10 https://www.claretbio.com/really-technology daily 0.75 2025-01-27 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1699211772853-97MYXWUQNLXPUJE7X3Y5/Really-banner6.png REALLY TECHNOLOGY https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/f33b3b1c-500e-4f8a-be70-f49c993a36e3/REALLY-hg-rNONE-website.png REALLY TECHNOLOGY - Make it stand out REALLY-rNONE workflow https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/4218932d-543b-463d-ba48-b384deea0263/Really-features.png REALLY TECHNOLOGY - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/297519c9-ad4c-417a-aecd-fde9a99c902f/REALLY-UHR-molmetrics.png REALLY TECHNOLOGY - Make it stand out Comparative molecular metrics of REALLY rNONE libraries vs a double-stranded library preparation method. The Agilent Universal Total Human RNA control was used as input. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/4390dbdf-f18d-47f1-8466-3705be6d3dac/REALLY-UHR-seqmetrics.png REALLY TECHNOLOGY - Make it stand out Comparative sequencing metrics of REALLY rNONE libraries vs a ds-Prep. Libraries were sequenced on a NextSeq500 to a depth >200M reads. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/c076ddb2-3e86-4c96-9d05-6335b4bc7b78/Really-Complexity.png REALLY TECHNOLOGY - Make it stand out Use lesser input in our library prep! REALLY rNONE generates libraries of higher complexity across a large input range. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/67b53e09-609d-4d5c-99d0-199e7862dad3/GBC-UHR.png REALLY TECHNOLOGY - Make it stand out Get better gene body coverage double-stranded Prep with REALLY rNONE. More uniform coverage of the transcripts allows accurate evaluation of RNA isoforms. Double-stranded approaches show a 5’ bias. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1036685c-4e95-4482-9f87-2b8a1b29db55/Really-concordance-UHR-corrected.png REALLY TECHNOLOGY - Make it stand out High concordance is observed between libraries. REALLY rNONE libraries had equivalent read-counts across a wide input range https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/221c0c9b-f01d-445e-b446-8068ab7cfc76/Depletion-series.png REALLY TECHNOLOGY - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/7546c357-2527-464c-9b19-ef23f6fdfc3b/Depletion-2panel.png REALLY TECHNOLOGY - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/91ab9163-c38d-411f-b185-ba9db38fbdb4/Correlation.png REALLY TECHNOLOGY - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/73d9a8b5-8c4b-4771-a0f8-735998e5ec3a/REALLY-FFPE-seqmetrics.png REALLY TECHNOLOGY - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/68d000b2-4db8-441b-8384-e3d40694cd81/REALLY-FFPE-data.png REALLY TECHNOLOGY - Make it stand out Sequencing metrics and comparison between REALLY rNONE™ libraries and dsPrep libraries. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1697433016449-NTJ1JRGK9B18A3BP8DLS/REALLY-brochure-thumbnail.png REALLY TECHNOLOGY - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/7150082c-1563-4d9b-af55-5f6c2adaa079/REALLY-hg-rNONE-thumbnail.png REALLY TECHNOLOGY - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.claretbio.com/forshear daily 0.75 2025-07-22 https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1736139597860-YBK1SM4QQKMNGBPJU1KW/ClaretBio-ForShear-webbanner.png ForShear Technology https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/7a4372fa-7a2f-45d6-a78e-1144b527f7a0/SRSLY-ForShear-Cartoon.png ForShear Technology https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/4d27c889-b2ee-4c39-aa8e-f883c3cdc733/ForShear-molecular-metrics.png ForShear Technology - Make it stand out ForShear>SRSLY Molecular Metrics. Libraries were prepared with the Horizon Discovery formalin compromised DNA set - Mild fcDNA (DIN ~7) and Severe fcDNA (DIN ~3). For Mild fcDNA, both SRSLY>ForShear protocol and the dsPrep protocol showed equivalent molecular metrics. However, for the severe fcDNA, SRSLY>ForShear generated high-quality libraries at lower PCR cycles with minimal adapter dimers. Overall, the SRSLY approach generated smaller libraries presumably due to the capture of nicked and short ssDNA. Download the collateral for more information. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/327dbbfc-2f31-41e2-a5bc-be590e096cbf/ForShear-WGS-metrics.png ForShear Technology ForShear>SRSLY Whole Genome Sequencing Metrics. The mapping metrics of the libraries showed that both approaches generated good quality libraries for both input types with comparable chimeric rates, genome coverage and GC content. However, ForShear>SRSLY generated libraries with lower duplication rates and higher complexity even with the severely damaged input types. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/86aac771-5f91-4a7b-99ed-48abb397ee26/ForShear-WES-metrics.png ForShear Technology - Make it stand out ForShear>SRSLY Whole Exome Enrichment Metrics- Here performed exome-enrichment with the Twist® Exome 2.0 capture panel after library prep with ForShear>SRSLY NanoPLus with UMI Addition. Deconvolution was performed using the srslyumi pipeline. Overall, the ClaretBio workflow had lower mean error rate based on consensus UMI groups. For severe fcDNA, the dsPrep showed lower mean target coverage and lower observed concordance with the expected allele frequency based on ddPCR. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1736194780976-J3PGLJJK9SUMTCYW9PEL/ClaretBio-Brochure-ForShear-thumbnail.png ForShear Technology - Downstream enrichment DOWNSTREAM TARGETED ENRICHMENT The Forshear + SRSLY workflow along with our UMI Additional module generates libraries of high complexity. This improves the accuracy of variant calling from degraded DNA of DIN as low as 2 from 10 ng inputs. Download the brochure to learn more. Write to us for sample data. https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1736194711546-FXRWMZPTNCSEYZT6HDKL/Bravo-Automation-Thumbnail.png ForShear Technology - automation friendly AUTOMATION FRIENDLY As an enzymatic fragmentation method, Forshear does not require instrumentation and be run on a variety of liquid handler. Read this app note or visit our automation page https://images.squarespace-cdn.com/content/v1/5bfc82067e3c3a5bd7e61c54/1736194727825-EVZECAW5TSU4TXS27NMJ/SingularGenomics-Thumbnail.png ForShear Technology - Make it stand out RUNS ON ALTERNATIVE SEQUENCERS Originally developed for Illumina, our libraries can also be run on a variety of sequencers. 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